Product Name :
SREBP1 Recombinant Rabbit Monoclonal Antibody [PSH04-61]
Predicted band size :
122 kDa
Observed band size :
80-100 kDa
Synonyms:
ADD 1 antibody bHLHd1 antibody Class D basic helix-loop-helix protein 1 antibody D630008H06 antibody Processed sterol regulatory element-binding protein 1 antibody SRBP1_HUMAN antibody SREBF 1 antibody SREBF1 antibody SREBP 1 antibody SREBP 1c antibody 展开
Function :
Sterol regulatory element-binding transcription factor 1 (SREBF1) also known as sterol regulatory element-binding protein 1 (SREBP-1) is a protein that in humans is encoded by the SREBF1 gene. This gene is located within the Smith–Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene. The isoforms are SREBP-1a and SREBP-1c (the latter also called ADD-1). SREBP-1a is expressed in the intestine and spleen, whereas SREBP-1c is mainly expressed in liver, muscle, and fat (among other tissues). SREBP-1 plays a key role in the induction of lipogenesis by the liver. mTORC1 is activated by insulin (a hormone of nutrient abundance) leading to increased production of SREBP-1c, which facilitates storage of fatty acids (excess nutrients) as triglycerides.
Antibody Type:
Recombinant Rabbit monoclonal Antibody
Immunogen :
Synthetic peptide within human SREBP1 aa 301-350 / 1,147.
Species reactivity:
Human
Verify application:
WB, IHC-P, IF-Cell
Coupling :
unconjugated
Clone number:
PSH04-61
RRID:
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing.Fmoc-Arg(Me,Pbf)-OH uses Aliquot store at -20℃.Azido-PEG1 Price Avoid repeated freeze / thaw cycles.PMID:33629722
Storage buffer solution:
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 122 kDa
Positive control :
HeLa cell lysate, HEK-293 cell lysate, MCF7 cell lysate, A549 cell lysate, SK-Br-3 cell lysate, human adrenal gland tissue, HeLa.