Product Name :
Septin 2 Recombinant Rabbit Monoclonal Antibody [JB41-30]
Predicted band size :
41 kDa
Observed band size :
Synonyms:
DIFF6 antibody hNEDD5 antibody KIAA0158 antibody NEDD 5 antibody NEDD5 antibody Neural precursor cell expressed developmentally down regulated 5 antibody Neural precursor cell expressed developmentally down regulated protein 5 antibody Pnutl3 antibody Protein NEDD5 antibody SEPT2 antibody 展开
Function :
Filament-forming cytoskeletal GTPase. Forms a filamentous structure with SEPT12, SEPT6, SEPT2 and probably SEPT4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation . Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements. In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes: probably acts by regulating the assembly of the tectonic-like complex (also named B9 complex) by localizing TMEM231 protein.
Antibody Type:
Recombinant Rabbit monoclonal Antibody
Immunogen :
Recombinant protein within Human Septin 2 aa 182-318 / 361.2-(3-Methyl-3H-diazirin-3-yl)ethan-1-ol uses
Species reactivity:
Human, Mouse, Rat
Verify application:
WB, IF-Cell, IF-Tissue, IHC-P, FC, IP
Coupling :
unconjugated
Clone number:
JB41-30
RRID:
AB_3070722
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing.674287-63-9 structure Aliquot store at -20℃ or -80℃.PMID:33579690 Avoid repeated freeze / thaw cycles.
Storage buffer solution:
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
41 kDa
Positive control :
Mouse brain tissue lysate, SiHa cell lysate, K562 cell lysate, HepG2, HUVEC, SH-SY5Y, rat brain tissue, human colon carcinoma tissue, human kidney tissue, K562.