Ogy, Cancer Center, Sun Yat-Sen University, No 651, Dongfeng Road East, Guangzhou 510060, China. 3Department of Pathology, Cancer Center, Sun Yat-Sen University, No 651, Dongfeng Road East, Guangzhou 510060, China. Received: 24 March 2013 Accepted: 16 July 2013 Published: 19 July 2013 References 1. Greenlee RT, Hill-Harmon MB, Murray T, Thun M: Cancer statistics, 2001. CA Cancer J Clin 2001, 51:15?six. two. Kirkali Z, Chan T, Manoharan M, Algaba F, Busch C, Cheng L, Kiemeney L, Kriegmair M, Montironi R, Murphy WM, Sesterhenn IA, Tachibana M, Weider J: Bladder cancer: epidemiology, staging and grading, and diagnosis. Urology 2005, 66:four?four. 3. Van Brussel JP, Mickisch GH: Prognostic factors in renal cell and bladder cancer. BJU Int 1999, 83:902?08. quiz 908?09. 4. Harvey KF, Pfleger CM, Hariharan IK: The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis. Cell 2003, 114:457?67. five. Lai ZC, Wei X, Shimizu T, Ramos E, Rohrbaugh M, Nikolaidis N, Ho LL, Li Y: Manage of cell proliferation and apoptosis by mob as tumor suppressor, mats. Cell 2005, 120:675?85. six. Edgar BA: From cell structure to transcription: Hippo forges a new path. Cell 2006, 124:267?73. 7. Hariharan IK, Bilder D: Regulation of imaginal disc development by tumorsuppressor genes in Drosophila. Annu Rev Genet 2006, 40:335?61. eight. Harvey K, Tapon N: The Salvador-Warts-Hippo pathway – an emerging tumour-suppressor network. Nat Rev Cancer 2007, 7:182?91. 9. Sudol M: Yes-associated protein (YAP65) is usually a proline-rich phosphoprotein that binds to the SH3 domain with the Yes proto-oncogene item. Oncogene 1994, 9:2145?152. ten. Bork P, Sudol M: The WW domain: a signalling web page in dystrophin? Trends Biochem Sci 1994, 19:531?33.11. Zender L, Spector MS, Xue W, Flemming P, Cordon-Cardo C, Silke J, Fan ST, Luk JM, Wigler M, Hannon GJ, Mu D, Lucito R, Powers S, Lowe SW: Identification and validation of oncogenes in liver cancer working with an integrative oncogenomic approach.Dirhodium tetraacetate web Cell 2006, 125:1253?267.Formula of Potassium (acetoxymethyl)trifluoroborate 12.PMID:33730164 Overholtzer M, Zhang J, Smolen GA, Muir B, Li W, Sgroi DC, Deng CX, Brugge JS, Haber DA: Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon. Proc Natl Acad Sci USA 2006, 103:12405?2410. 13. Modena P, Lualdi E, Facchinetti F, Veltman J, Reid JF, Minardi S, Janssen I, Giangaspero F, Forni M, Finocchiaro G, Genitori L, Giordano F, Riccardi R, Schoenmakers EF, Massimino M, Sozzi G: Identification of tumor-specific molecular signatures in intracranial ependymoma and association with clinical traits. J Clin Oncol 2006, 24:5223?233. 14. Steinhardt AA, Gayyed MF, Klein AP, Dong J, Maitra A, Pan D, Montgomery EA, Anders RA: Expression of Yes-associated protein in popular solid tumors. Hum Pathol 2008, 39:1582?589. 15. Xu MZ, Yao TJ, Lee NP, Ng IO, Chan YT, Zender L, Lowe SW, Poon RT, Luk JM: Yes-associated protein is definitely an independent prognostic marker in hepatocellular carcinoma. Cancer 2009, 115:4576?585. 16. Zhao B, Wei X, Li W, Udan RS, Yang Q, Kim J, Xie J, Ikenoue T, Yu J, Li L, Zheng P, Ye K, Chinnaiyan A, Halder G, Lai ZC, Guan KL: Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell speak to inhibition and tissue development control. Genes Dev 2007, 21:2747?761. 17. Dong J, Feldmann G, Huang J, Wu S, Zhang N, Comerford SA, Gayyed MF, Anders RA, Maitra A, Pan D: Elucidation of a universal size-control mechanism in Drosophila and mammals. Cell 2007, 130:1120?133. 18. Camargo FD, Gokhale S, Johnnidis JB, Fu D, Bell.