Sensory block onset at T4 have been 257.1?7.5 and 194.5?0.1 sec inGroupCandMgrespectively(p=0.015).TimetofirstpostoperativeanalgesicrequestwassignificantlyprolongedinGroupMgthan inGroupC(246.1?two.8and137.4?0.5min,respectively,p0.001; with a mean difference of 108.six min and 95 CI between 81.six and 135.7).Sideeffectsweresimilarinbothgroups.GroupCrequired significantlymorefluids. Conclusion:TreatmentwithIVMgSO4 in extreme pre-eclamptic parturients significantly prolonged the time for you to 1st analgesic request when compared with healthy preterm parturients, which may possibly be attributed for the opioid potentiation of magnesium. (Balkan Med J2014;31:143-8). Crucial Words: Caesarean section, magnesium sulphate, pre-eclampsia, spinal anaesthesiaMagnesium is definitely an necessary component of therapy in serious preeclampsiaforeclampsiaprophylaxis.Besidesitsanticonvulsant and neuroprotective properties, this bivalent cation is an N-methyl-D-aspartate (NMDA) receptor antagonist and is often cited within the anaesthesia literature for its anti-nociceptiveeffectswithconflictingresults(1,2).Innon-obstetric populations, many research have reported intravenous (IV) magnesium administration to become useful for postoperative analgesiafollowingneuraxialanaesthesia(3-6),whereasone studycouldnotdemonstratethiseffect(7).15418-29-8 In stock Thiscontroversy can in aspect originate in the truth that, in wholesome humans, thepassageofmagnesiumtocerebrospinalfluid(CSF)islim-itedwhenadministeredintravenously(1).Even so,thismay not be true for pre-eclamptic sufferers as vascular permeability alterations in pre-eclamptic patients may possibly adjust the transfer of magnesium to the CSF (eight).You will find only a few research exploringmagnesiumpassagetoCSFinthepresenceofpreeclampsia(9-11).Indeed,inpre-eclampticparturientsreceivingIVmagnesiumsulphate(MgSO4),Thurnauetal.1309982-17-9 supplier (9)found smallbutsignificantincreasesinCSFmagnesiumlevels. Neuraxial anaesthesia, if not contraindicated, has recently been shown to become the system of choice in pre-eclamptic parturientsforcaesareandelivery(12).Magnesiumtreatmentin severely pre-eclamptic sufferers might also supply an advantageAddress for Correspondence:Dr.T ay kanSeyhan,DepartmentofAnesthesiology,stanbulUniversitystanbulFacultyofMedicine,stanbul,Turkey.PMID:33555018 Phone: +90 212 631 87 67 e-mail: tulay2000@gmail Received: 09.09.2013 Accepted: 07.05.2014 ?DOI: 10.5152/balkanmedj.2014.13116 Available at balkanmedicaljournal.org144 foranti-nociceptionfollowingneuraxialanaesthesia;having said that,thereisnostudyexploringthiseffect.Inthisprospective observationalstudy,wetestedthehypothesisthatIVMgSO4 therapy in serious pre-eclampsia would prolong the time for you to firstanalgesicrequestfollowingfentanylandbupivacainespinal anaesthesia in comparison with healthy non-pre-eclamptic preterm parturients. MATERIAL AND METHODSAccording to our institutional protocol, all severely pre-eclamptic patients are admitted to the obstetric unit after diagnosed, as per the recommendations (13), and antihypertensive medication with 24-hour IVMgSO4 treatmentisstarted.Inpatientswithgestationalage34 weeks, as long as the foetus plus the mother are steady, delivery is delayed to attain foetal lung maturity with conservative treatment. Inpatientswithgestationalage34weeks,deliveryisplannedafter stabilisation in the mother. MgSO4 therapy includes a bolus of four.5 g MgSO4 given over 10-15 minutes inside the labour ward followed by an infusion of two g/h till transfer towards the operating space. Right after acquiring approval of Clinical Analysis Ethics Committee of our institution and informed consent f.