Product Name :
2-Deoxy-D-glucose (CAS 154-17-6)
Synonym :
2-Deoxy-D-glucose also known as 2-Deoxy-D-arabinohexose; 2-Deoxyglucose; 2-deoxy-d-arabino-hexos; 2-deoxy-d-glucos; 2-deoxy-d-mannose; 2-deoxy-glucos; 2-desoxy-d-glucose; D-Arabino-2-deoxyhexose; D-2-GLUCODESOSE; 2-DEOXY-D-ARABINOHEXOSE; 2-DEOXYGLUCOSE; 2-Deoxy-D-Arabino; 6-HYDROXYMETHYL-5-METHYL-TETRAHYDRO-PYRAN-2,4,5-TRIOL; D-arabino-Hexose, 2-deoxy-; DEOXY-D-GLUCOSE, 2-(P); (3R,4S,5R)-3,4,5,6-tetrahydroxyhexanal
Application :
2-Deoxy-D-glucose is an apoptosis and HXK inhibitor that lowers ATP levels in cancer cell lines and has shown to be taken up by glial cells incubated with insulin
CAS:
154-17-6
Purity:
≥98%
Molecular Weight:
164.16
Formula :
C6H12O5
Physical state:
Solid
solubility :
Soluble in water.
Shipping Condition :
Store at 4° C
Melting point:
146-147° C
SMILES:
C1[C@H]([C@@H]([C@H](OC1O)CO)O)O
References:
:Effect of 2-deoxy-D-glucose on aminoacids metabolism in rats′ cerebral cortex slices. | Muller, AP., et al. 2006. Neurochem Res. 31: 417-22. PMID: 16733818Differential toxic mechanisms of 2-deoxy-D-glucose versus 2-fluorodeoxy-D-glucose in hypoxic and normoxic tumor cells. | Kurtoglu, M., et al. 2007. Antioxid Redox Signal. 9: 1383-90. PMID: 17627467Enhancement of radiation and chemotherapeutic drug responses by 2-deoxy-D-glucose in animal tumors. | Gupta, S., et al. 2009. J Cancer Res Ther. 5 Suppl 1: S16-20. PMID: 20009287Cytotoxicity, radiosensitization, and chemosensitization of tumor cells by 2-deoxy-D-glucose in vitro. | Dwarakanath, BS. 2009. J Cancer Res Ther. 5 Suppl 1: S27-31. PMID: 20009290Protection of normal cells and tissues during radio- and chemosensitization of tumors by 2-deoxy-D-glucose.N2-Isobutyryl-2′-O-methylguanosine supplier | Farooque, A.Formula of Metformin , et al. 2009. J Cancer Res Ther. 5 Suppl 1: S32-5. PMID: 200092912-Deoxy-D-glucose activates autophagy via endoplasmic reticulum stress rather than ATP depletion. | Xi, H., et al. 2011. Cancer Chemother Pharmacol. 67: 899-910. PMID: 20593179Focal, periocular delivery of 2-deoxy-D-glucose as adjuvant to chemotherapy for treatment of advanced retinoblastoma. | Piña, Y., et al. 2010. Invest Ophthalmol Vis Sci. 51: 6149-56. PMID: 207028302-Deoxy-D-glucose targeting of glucose metabolism in cancer cells as a potential therapy. | Zhang, D., et al. 2014. Cancer Lett. 355: 176-83. PMID: 25218591Effect of 2-deoxy-D-glucose on gellan gum biosynthesis by Sphingomonas paucimobilis. | Zhu, G., et al. 2019. Bioprocess Biosyst Eng. 42: 897-900. PMID: 306716272-deoxy D-glucose treatment does not elicit a hair growth response in alopecia areata. | Sundberg, JP., et al. 2019. Exp Dermatol. 28: 1091-1093. PMID: 313231492-Deoxy-d-Glucose and Its Analogs: From Diagnostic to Therapeutic Agents.PMID:33481723 | Pajak, B., et al. 2019. Int J Mol Sci. 21: PMID: 319057452-Deoxy-D-glucose and combined 2-Deoxy-D-glucose/albendazole exhibit therapeutic efficacy against Echinococcus granulosus protoscoleces and experimental alveolar echinococcosis. | Xin, Q., et al. 2022. PLoS Negl Trop Dis. 16: e0010618. PMID: 35849619Role of 2-deoxy-D-glucose in the inhibition of phagocytosis by mouse peritoneal macrophage. | Sung, SS. and Silverstein, SC. 1985. Biochim Biophys Acta. 845: 204-15. PMID: 3838908Insulin binds to specific receptors and stimulates 2-deoxy-D-glucose uptake in cultured glial cells from rat brain. | Clarke, DW., et al. 1984. J Biol Chem. 259: 11672-5. PMID: 6384211Inhibition of doxorubicin-induced apoptosis in vivo by 2-deoxy-D-glucose. | Thakkar, NS. and Potten, CS. 1993. Cancer Res. 53: 2057-60. PMID: 8481907