Product Name :
PDX1 Recombinant Rabbit Monoclonal Antibody [JM62-45]
Predicted band size :
Observed band size :
Synonyms:
Glucose sensitive factor antibody Glucose-sensitive factor antibody GSF antibody IDX 1 antibody IDX-1 antibody IDX1 antibody Insulin promoter factor 1 antibody Insulin promoter factor 1 homeodomain transcription factor antibody Insulin upstream factor 1 antibody IPF 1 antibody 展开
Function :
Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5′-[CT]TAAT[TG]-3′. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell.
Antibody Type:
Recombinant Rabbit monoclonal Antibody
Immunogen :
Synthetic peptide within Human PDX1 234-283 / 283.
Species reactivity:
Human
Verify application:
WB, IHC-P, IF-Cell, IF-Tissue
Coupling :
unconjugated
Clone number:
JM62-45
RRID:
AB_3070627
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing.2-(3,5-Dimethylphenyl)acetic acid Formula Aliquot store at -20℃ or -80℃.1445951-40-5 Chemscene Avoid repeated freeze / thaw cycles.PMID:33716140
Storage buffer solution:
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 31 kDa
Positive control :
Hela cell lysates, human pancreas tissue, human gallbladder tissue, human stomach tissue.