Product Name :
3-Iodo-L-tyrosine (CAS 70-78-0)
Synonym :
3-Iodo-4-hydroxyphenylalanine
Application :
3-Iodo-L-tyrosine is a Tyrosine hydroxylase inhibitor.
CAS:
70-78-0
Purity:
Molecular Weight:
307.09
Formula :
C9H10INO3
Physical state:
Solid
solubility :
Soluble in Dilute Aqeous Acid and Dilute Aqeous Base
Shipping Condition :
Store at -20° C
Melting point:
195-203° C
SMILES:
C1=CC(=C(C=C1C[C@@H](C(=O)O)N)I)O
References:
:The stimulation of human prolactin secretion by 3-Iodo-L-tyrosine. | Smythe, GA., et al. 1975. J Clin Endocrinol Metab. 40: 714-6. PMID: 1127080Use of a boroxazolidone complex of 3-iodo-L-tyrosine for palladium-catalyzed cross-coupling. | Walker, WH. and Rokita, SE. 2003. J Org Chem. 68: 1563-6. PMID: 12585904Structural basis of nonnatural amino acid recognition by an engineered aminoacyl-tRNA synthetase for genetic code expansion. | Kobayashi, T., et al. 2005. Proc Natl Acad Sci U S A. 102: 1366-71. PMID: 15671170Genetic encoding of 3-iodo-L-tyrosine in Escherichia coli for single-wavelength anomalous dispersion phasing in protein crystallography. | Sakamoto, K., et al. 2009. Structure. 17: 335-44. PMID: 19278648Dissecting cell signaling pathways with genetically encoded 3-iodo-L-tyrosine. | Hayashi, A., et al. 2011. Chembiochem. 12: 387-9. PMID: 21290538Excess amounts of 3-iodo-l-tyrosine induce Parkinson-like features in experimental approaches of Parkinsonism. | Fernández-Espejo, E. and Bis-Humbert, C. 2018. Neurotoxicology. 67: 178-189. PMID: 29885340An assay for screening xenobiotics for inhibition of rat thyroid gland peroxidase activity. | Price, RJ., et al. 2020. Xenobiotica. 50: 318-322. PMID: 31180273Associative learning in larval and adult Drosophila is impaired by the dopamine-synthesis inhibitor 3-Iodo-L-tyrosine.133464-46-7 Computational Chemistry Data | Thoener, J., et al. 2021. Biol Open. 10: PMID: 34106227In vitro assays for characterization of distinct multiple catalytic activities of thyroid peroxidase using LC-MS/MS. | Tater, A.1260663-93-1 Formula , et al.PMID:33682657 2021. Curr Res Toxicol. 2: 19-29. PMID: 34345847Reserpine and PCPA reduce heat tolerance in Drosophila melanogaster. | Bressan, GN., et al. 2023. Life Sci. 318: 121497. PMID: 36780938A simple procedure for the assay of brain biogenic amines by selected-ion monitoring: its application to the elucidation of the mechanism of prolactin release induced by 3-iodo-L-tyrosine. | Smythe, GA., et al. 1979. Aust J Biol Sci. 32: 335-41. PMID: 508206Different acute effects of the tyrosine hydroxylase inhibitors alpha-methyl-p-tyrosine and 3-iodo-L-tyrosine on hypothalamic noradrenaline activity and adrenocorticotrophin release in the rat. | Smythe, GA. and Bradshaw, JE. 1983. Aust J Biol Sci. 36: 519-23. PMID: 6144300Effects of 3-iodo-L-tyrosine, a tyrosine hydroxylase inhibitor, on eye pigmentation and biogenic amines in the planarian, Dugesia dorotocephala. | Ness, DK., et al. 1996. Fundam Appl Toxicol. 30: 153-61. PMID: 8812261